Experience With Peptides (BPC-157 & TB-500) Chronic Knee Pain

[MLX]

Hey everyone,
I’m 23 years old, 6'0" (1.84m), and for over two years I struggled with chronic knee pain. It started after a mountain run when I was around 96 kg (~212 lbs). Ever since that day, I had a constant stabbing pain in my knee (mainly on the inside/medial side). I couldn’t do leg training for months, and even later the pain always came back.
I tried pretty much everything: magnet therapy, cortisone treatments, sauna, stretching, mobility work – nothing brought lasting relief. After two years of this, I finally came across peptides. About two months ago, I decided to give them a try.

BPC-157​

• Typical dosage: 250–500 mcg per day, split into 1–2 injections
• Injection method: subcutaneous into the tissue around the joint (never directly inside)
• Rotation: inject at different spots around the knee to avoid hitting the same area repeatedly
• Effect: works slowly; on its own I didn’t notice dramatic improvements, but it likely laid the foundation for healing

TB-500​

• Loading phase: 2–2.5 mg per week (split into multiple injections) for 4–6 weeks
• Maintenance (optional): 1–2 mg every 1–2 weeks
• Injection method: subcutaneous or intramuscular (systemic effect, not just local)
• Effect: after ~2 weeks, pain reduced dramatically and mobility came back

Results​

• Currently pain-free
• Can squat and train legs normally again
• Kept up some sauna, mobility, and stretching work on the side (nothing extreme, but consistent)

Takeaway​

• BPC-157: slow and subtle, sets the stage for recovery
• TB-500: the real gamechanger, brought the breakthrough
• After 2 years of no real progress, I’m finally back to full training without knee pain

 

[Donvitosharkone]

Man, this log hits home for anyone who’s dealt with nagging joint pain.

Two years of stabbing knee pain is no joke, especially when it takes you out of leg training.

The fact you tried all the standard routes, cortisone, magnet therapy, sauna, mobility and all the sh**ty things but nothing worked shows how brutal chronic injuries can be. Respect for pushing through that long.

The peptide approach here is honestly textbook.

BPC-157 is subtle, like you said, it doesn’t feel dramatic (and does not have to!!) but it lays the groundwork for tissue repair. The way you rotated injections around the joint is exactly how you avoid scar tissue build up and maximize local benefits.

TB-500 on top of that is the golden standard of a real gamechanger. Two weeks in and pain dropping while mobility comes back, that’s the kind of turnaround people hope for but rarely get. The systemic effect of TB-500 makes sense, seems you nailed the dosing right with a proper loading phase before tapering down.

Your results confirms all: pain free, squatting again, and full leg training after two years of stop-and-go. SOOOOO!! That’s not placebo… !

that’s repair in action. Plus, the fact you kept up sauna and mobility alongside peptides shows you built a full environment for healing instead of just hoping for a magic fix.

If there’s one thing I’d suggest:

keeping a closer eye on long-term tendon integrity.

Just because the pain’s gone doesn’t mean the tissue’s bulletproof yet. Gradual load progression and maybe one more short maintenance pulse of TB-500 could help lock in the recovery for good.

Overall, this is one of those comeback stories that shows why peptides deserve more attention in sports medicine. From sidelined and frustrated to training legs again pain-free

it’s the kind of win every lifter with chronic pain dreams about…. Thanks for sharing it!!

Shark!

 

[MLX]

Man, this log hits home for anyone who’s dealt with nagging joint pain.

Two years of stabbing knee pain is no joke, especially when it takes you out of leg training.

The fact you tried all the standard routes, cortisone, magnet therapy, sauna, mobility and all the sh**ty things but nothing worked shows how brutal chronic injuries can be. Respect for pushing through that long.

The peptide approach here is honestly textbook.

BPC-157 is subtle, like you said, it doesn’t feel dramatic (and does not have to!!) but it lays the groundwork for tissue repair. The way you rotated injections around the joint is exactly how you avoid scar tissue build up and maximize local benefits.

TB-500 on top of that is the golden standard of a real gamechanger. Two weeks in and pain dropping while mobility comes back, that’s the kind of turnaround people hope for but rarely get. The systemic effect of TB-500 makes sense, seems you nailed the dosing right with a proper loading phase before tapering down.

Your results confirms all: pain free, squatting again, and full leg training after two years of stop-and-go. SOOOOO!! That’s not placebo… !

that’s repair in action. Plus, the fact you kept up sauna and mobility alongside peptides shows you built a full environment for healing instead of just hoping for a magic fix.

If there’s one thing I’d suggest:

keeping a closer eye on long-term tendon integrity.

Just because the pain’s gone doesn’t mean the tissue’s bulletproof yet. Gradual load progression and maybe one more short maintenance pulse of TB-500 could help lock in the recovery for good.

Overall, this is one of those comeback stories that shows why peptides deserve more attention in sports medicine. From sidelined and frustrated to training legs again pain-free

it’s the kind of win every lifter with chronic pain dreams about…. Thanks for sharing it!!

Shark!

I’ve noticed a skin rash on my wrist—especially on the inner side—after using BPC-157, possibly related to the bacteriostatic water as well. Whenever I stop the peptide, the rash disappears within about 1.5 days. When I resume, it reappears in roughly the same time frame. This is the only negative effect I’ve experienced so far, and I’m willing to accept it because the treatment has significantly reduced my pain.

 

[Donvitosharkone]

I’ve noticed a skin rash on my wrist—especially on the inner side—after using BPC-157, possibly related to the bacteriostatic water as well. Whenever I stop the peptide, the rash disappears within about 1.5 days. When I resume, it reappears in roughly the same time frame. This is the only negative effect I’ve experienced so far, and I’m willing to accept it because the treatment has significantly reduced my pain.

Well, under that is a minor issue compared with the results you have got!!

Please, do not hesitate reaching us once you feel ready to change your strategy from a healing to a mass growing machine

 

[electromecca]

Add ipamorelin next time

 

[BellaMasculine]

Have you checked why you have knee pain ?

If you say it's since you've started running :

• Do a analysis of your walk and buy the perfect shoes for you (and yes good running shoes are over 150€)
• Start "running the right way" many people are using the "wrong running technique"
• Check your hips , most of the time hip problems are causing knee pain

I had exactly the same years ago and my main problem was hips and wrong shoes .

 

[MLX]

Have you checked why you have knee pain ?

If you say it's since you've started running :

• Do a analysis of your walk and buy the perfect shoes for you (and yes good running shoes are over 150€)
• Start "running the right way" many people are using the "wrong running technique"
• Check your hips , most of the time hip problems are causing knee pain

I had exactly the same years ago and my main problem was hips and wrong shoes .

i have 2 pairs one was 180€ and the other one was arround 200€ my hips are fine it came after i ran for 35min downhill at 93kg

 

[BellaMasculine]

i have 2 pairs one was 180€ and the other one was arround 200€ my hips are fine it came after i ran for 35min downhill at 93kg

Running downhill isn't good tbh especially for a longer time . The movements of your kneecap by running downhill can cause that. Better go uphill or on straight roads, downhill only slowly and for a short time.

 

[Alex777]

Running downhill:
-eccentric load on the quadriceps.
-enormous pressure on the patellofemoral joint.
35 minutes continuously. Even for a trained runner this is a lot — and for a bodybuilder, even more so.
Bodyweight: 93 kg

When running downhill, knee load can exceed 5–7× bodyweight on every step. Even very expensive running shoes (€180–200) cannot override biomechanics.What would John Meadows say (his philosophy)

Meadows was not a fan of running for bodybuilders. His approach:
“If your warm-up beats up your joints more than your workout — you’re doing it wrong.”
His key principles:
Knees and elbows should be protected, not “hardened”
Warm-up = blood flow + mobility, not impact
Joint pain is a signal, not weakness. Is running optimal as a warm-up for bodybuilding?
In most cases — NO
Especially if:
bodyweight > 85 kg
you train legs with weights
you have a history of knee pain.
Running is high-impact cyclic loading, while bodybuilding is about control and tension.

What to use instead (Meadows-style options)
Best cardio warm-ups
Stationary bike (10–12 min)
— minimal knee stress

Elliptical trainer
— very joint-friendly

Incline walking (NOT downhill)
— if you really want the treadmill

How Meadows would warm up the knees (example)
Before leg training or any lower-body work:
Light cardio — 8–10 minutes
Very light leg extensions — 2×20
Leg curls — 2×20

Bodyweight squats — slow and controlled
Only then — working weights
The goal is to lubricate the joint, not destroy it.
What to do now if your knee hurts
Not a medical diagnosis — just coaching logic:
Remove running (especially downhill) for 2–3 weeks

No jumping, forward lunges, or deep-range leg press
Light, non-impact cardio
More hamstrings and glutes

Technique control (knees not collapsing inward)
If pain is sharp, worsening, or there is swelling — see a sports doctor.
Short and honest:
The pain did not come from the shoes — it came from:
downhill running, bodyweight, duration.

For a bodybuilder, running is not an optimal warm-up.
John Meadows would choose:
blood flow, control, and joint health
If you want to grow long-term — you must protect your knees.

You’re not “broken.”
You simply overloaded biomechanics that weren’t designed for your type of body.
You train like a bodybuilder —
so your cardio and warm-ups should be those of a bodybuilder, not a marathon runner.

 

[MLX]

Running downhill:
-eccentric load on the quadriceps.
-enormous pressure on the patellofemoral joint.
35 minutes continuously. Even for a trained runner this is a lot — and for a bodybuilder, even more so.
Bodyweight: 93 kg

When running downhill, knee load can exceed 5–7× bodyweight on every step. Even very expensive running shoes (€180–200) cannot override biomechanics.What would John Meadows say (his philosophy)

Meadows was not a fan of running for bodybuilders. His approach:
“If your warm-up beats up your joints more than your workout — you’re doing it wrong.”
His key principles:
Knees and elbows should be protected, not “hardened”
Warm-up = blood flow + mobility, not impact
Joint pain is a signal, not weakness. Is running optimal as a warm-up for bodybuilding?
In most cases — NO
Especially if:
bodyweight > 85 kg
you train legs with weights
you have a history of knee pain.
Running is high-impact cyclic loading, while bodybuilding is about control and tension.

What to use instead (Meadows-style options)
Best cardio warm-ups
Stationary bike (10–12 min)
— minimal knee stress

Elliptical trainer
— very joint-friendly

Incline walking (NOT downhill)
— if you really want the treadmill

How Meadows would warm up the knees (example)
Before leg training or any lower-body work:
Light cardio — 8–10 minutes
Very light leg extensions — 2×20
Leg curls — 2×20

Bodyweight squats — slow and controlled
Only then — working weights
The goal is to lubricate the joint, not destroy it.
What to do now if your knee hurts
Not a medical diagnosis — just coaching logic:
Remove running (especially downhill) for 2–3 weeks

No jumping, forward lunges, or deep-range leg press
Light, non-impact cardio
More hamstrings and glutes

Technique control (knees not collapsing inward)
If pain is sharp, worsening, or there is swelling — see a sports doctor.
Short and honest:
The pain did not come from the shoes — it came from:
downhill running, bodyweight, duration.

For a bodybuilder, running is not an optimal warm-up.
John Meadows would choose:
blood flow, control, and joint health
If you want to grow long-term — you must protect your knees.

You’re not “broken.”
You simply overloaded biomechanics that weren’t designed for your type of body.
You train like a bodybuilder —
so your cardio and warm-ups should be those of a bodybuilder, not a marathon runner.

im not a bodybuilder im a mma fighter but thanks for the info appreciate it