Expert Answered MOTS-C and GHK-Cu

Back MOTS-C and GHK-Cu
BPC-157, TB-500, ipamorelin, MOTS-C, GHK-Cu and other peptides.
Tina

Tina

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Ho iniziato lunedì con GHK-CU (2mg).
Volevo chiedere se posso aggiungere anche il mots-c. Visto che sono ancora sotto retatrudite.

Ho letto la tua presentazione. Ti interessi anche della longevità? È una cosa che mi interessa moltissimo. Prendo vari integratori. Magari puoi darmi una dritta anche lì se hai tempo e voglia.
 
As for the peptides, I think adding MOTS-C as an experiment could be useful. Use 2–3 mg on days without strength training, or in the morning if your strength workout is in the evening. If you subjectively feel more energy, then the compound is working for you.

As for the duration of the cycle, since this peptide doesn’t yet have clinically approved protocols, I wouldn’t run it for too long. 4–6 weeks will be enough at first to understand the effect. Later, if you tolerate it well, you can increase it to 8–10 weeks, but I wouldn’t turn it into something you use continuously. After all, we don’t know exactly how the peptide may affect humans and what else it may influence. It’s currently in Phase 2 clinical trials, but that’s clearly not enough.

Please write a list of the supplements you’re currently taking and the dosages.

Regarding your home gym and training — did the painful area bother you during your vacation? What’s the situation with the discomfort now?

P.S. For everyone reading this thread — Tina and I were talking on Telegram before she posted here, so this conversation is a continuation of a consultation that started some time ago.
 
Prossimi settimana allora inizio con mots-c. Ma devo integrare anche il magnesio?

Gli integratori che prendo sono:

NMN 500 mg
TMG 500 mg
UROLITINA A 500 mg
TRANS-RESERVATROLO 250 mg
VITAMINA C 1gr
COLLAGENE 15 gr

Sera:
SPERIMIDINA 2,5 mg

In vacanza non ho avuto grandi fastidi. Lunedì mi sono allenata e ho fatto Squat e affondi e non ho sentito dolore. Sento solo tirare gluteo psoas e quadricipite. Insomma tutto il lato destro. Sento sollievo se faccio pressione con le mani o con il rullo.
Dici di cambiare solo impostazione squat?

Grazie 😊
 
Tina said:
Prossimi settimana allora inizio con mots-c. Ma devo integrare anche il magnesio?

Gli integratori che prendo sono:

NMN 500 mg
TMG 500 mg
UROLITINA A 500 mg
TRANS-RESERVATROLO 250 mg
VITAMINA C 1gr
COLLAGENE 15 gr

Sera:
SPERIMIDINA 2,5 mg

In vacanza non ho avuto grandi fastidi. Lunedì mi sono allenata e ho fatto Squat e affondi e non ho sentito dolore. Sento solo tirare gluteo psoas e quadricipite. Insomma tutto il lato destro. Sento sollievo se faccio pressione con le mani o con il rullo.
Dici di cambiare solo impostazione squat?

Grazie 😊
Click to expand...
Okay, I understand the goal you’re trying to achieve with these supplements. I’d add some basics like magnesium, B vitamins (active forms but in low doses), antioxidants such as NAC 1200 mg, and Ubiquinol. It would also be good to get some bloodwork done to check for deficiencies, iron metabolism, and blood biochemistry, and then we can understand which supplements actually make sense to add.

Regarding the tightness in your glute, psoas, and quadriceps, I’d think about addressing this now. What it looks like at the moment is some kind of functional compensation in your body at an early stage. If you figure out what needs fixing now, you can avoid further problems. If you ignore it, you may end up with chronic low-grade injuries that interfere with your training.

For now, the minimum you can do is remove any exercises that cause these sensations. Do you do any mobility or stretching work at the end of your strength training?

As for changing your technique, it’s probably harder than it seems because your body will naturally try to move according to the pattern it already knows. But it can be fixed, you just need to take a step back and start from scratch, and that often means finding a clever way to trick the brain. But more on that a little later. You may need a specialist who works with things like “reprogramming” movement patterns. I know someone who does this.
 
Quanta grandezza dovremmo assumere?

Faccio la lista di esami che mi avevi già consigliato?

NO ...purtroppo non sono costante nel fare mobilità e stretching. È un mio sbaglio lo so. Dovrei farlo sempre.
 
Quanto magnesio dovrei assumere?
Ubiquinolo a cosa serve?

Tolgo gli esercizi che mi danno fastidio. Come alleno poi i glutei? Sai che mi alleno in Box. Hai delle alternative da consigliarmi?
 
Tina said:
Quanto magnesio dovrei assumere?
Ubiquinolo a cosa serve?

Tolgo gli esercizi che mi danno fastidio. Come alleno poi i glutei? Sai che mi alleno in Box. Hai delle alternative da consigliarmi?
Click to expand...
  • Magnesium (if bisglycinate): around 1500 mg per day
  • For B vitamins, I recommend using this complex: https://driadashop.to/allaes-orange-b, it already has the right dosages
  • NAC 1200 mg
  • Ubiquinol 100 mg. Ubiquinol is the reduced, biologically active form of CoQ10. Compared to ubiquinone, it generally has better bioavailability, which can be especially relevant as we age, when CoQ10 absorption and metabolism may become less efficient.

    CoQ10 is involved in the mitochondrial respiratory chain, transferring electrons and supporting the production of ATP — the main source of cellular energy. In addition, the reduced form of CoQ10 acts as an antioxidant, protecting cell membranes and lipoproteins from oxidative damage.
Yes, get the tests from this list. I’ve also added zinc and copper here.

Hematology
  • Complete blood count
Iron metabolism
  • Ferritin
  • Transferrin
  • TIBC / transferrin saturation
Lipid profile
  • LDL-C
  • HDL-C
  • Triglycerides
  • ApoB
  • Lp(a) — it’s enough to measure it at least once in your lifetime
Carbohydrate metabolism
  • Fasting glucose
  • HbA1c
Liver
  • ALT
  • AST
  • GGT
  • ALP
  • Total bilirubin
  • Albumin
  • Total protein
Kidneys
  • Creatinine
  • Cystatin C + eGFR
  • Urea
Thyroid
  • TSH
  • Free T4
Deficiencies / nutrition
  • 25-OH Vitamin D
  • Vitamin B12
  • Folate
  • Zinc
  • Copper
 
Tina said:
Quanto magnesio dovrei assumere?
Ubiquinolo a cosa serve?

Tolgo gli esercizi che mi danno fastidio. Come alleno poi i glutei? Sai che mi alleno in Box. Hai delle alternative da consigliarmi?
Click to expand...
As for mobility training, here’s why it’s important for you. Years of powerlifting can cause some muscle groups to become much more developed while others lag behind. And this builds up over the years. The stronger, more developed muscles stay under constant tension and start affecting your posture. Because of this, your body has to create compensations in movement to maintain balance, which puts extra stress on certain areas. This increases the risk of injury, and it’s also important to consider the wear and tear on the tendons.

Without seeing photos and videos of your technique, I can’t say exactly what isn’t working properly, but judging by your complaint and considering your background, we can already assume that some muscles/tendons are taking on more load than they should. Lower back overload, hyperlordosis, and the issues that come with it are very common in powerlifting. When even one link in the chain starts to fail, compensation continues further along the chain.

Right now, without any kind of assessment, I can only give general recommendations — choose exercises where you don’t feel discomfort during the exercise or the next day.

You could try replacing back squats with plié squats. Do you squat with a low-bar or high-bar position? You can record a video from the front and from the side, and I’ll try to see if there are any weak points in your technique.
 
Tengo il bilanciere alto nello Squat.

Ti farò il video per mostrarti l'esecuzione.

Intanto cercherò di fare più mobilità.

Sicuramente i 9 anni di powerlifting con carichi pesanti hanno lasciato il segno. Ho toccato i 180kg di Squat ei 192,5kg di Deadlift equipaggiato.

Adesso non faccio più quei carichi ma il fastidio c'è 😮‍💨
 
Ciao Tina, con quei numeri hai sicuramente tanta esperienza sotto il bilanciere! Il fastidio però merita una valutazione di persona: dal racconto non possiamo sapere se venga da muscolo, tendine, articolazione o nervo, e non significa automaticamente che nove anni di allenamento abbiano causato danni. Un fisioterapista può aiutarti a scegliere movimenti e carichi tollerabili.

Sui peptidi, farei una pausa prima di aggiungere MOTS-C a GHK-Cu e retatrutide. L’idea di migliorare il metabolismo cellulare è interessante, ma non abbiamo prove cliniche solide che questa combinazione migliori la longevità o sia sicura. Sentire più energia non dimostra da solo che un peptide stia funzionando.

Per il magnesio controlla la voce ‘magnesio elementare’ sull’etichetta: il peso del bisglicinato non è la quantità di magnesio. Non partirei da una cifra senza chiarire quella differenza e la funzione renale con medico o farmacista. Capisco la voglia di ottimizzare tutto; scegliere poche cose con un motivo chiaro rende anche più facile capire cosa ti aiuta.
 
Grazie. Si ho già provveduto al fisioterapista. Vediamo cosa mi consiglia.

Infatti ero in dubbio se usare anche il mots-c o aspettare. Ho sentito tante versioni contrastanti.

Cosa esattamente devo controllare per il "magnesio elementare"? Scusa ma non ho capito bene.
 
Ciao Tina, figurati! Cerca nella tabella nutrizionale la riga Magnesio, oppure di cui magnesio, e controlla se il valore è per capsula o per dose giornaliera. Quella è la quantità di magnesio elementare, cioè il minerale vero e proprio. Per esempio, se una dose di due capsule contiene bisglicinato di magnesio 1.000 mg, di cui magnesio 140 mg, assumi 140 mg di magnesio con due capsule, quindi 70 mg con una. È solo un esempio: non tutti i prodotti hanno la stessa composizione, quindi non ricaverei il valore dal numero grande sul davanti della confezione. Se vuoi, manda una foto della tabella e della porzione consigliata, così possiamo leggerla insieme senza indovinare. Bene che tu abbia già contattato il fisioterapista!
 
Tina said:
Tengo il bilanciere alto nello Squat.

Ti farò il video per mostrarti l'esecuzione.

Intanto cercherò di fare più mobilità.

Sicuramente i 9 anni di powerlifting con carichi pesanti hanno lasciato il segno. Ho toccato i 180kg di Squat ei 192,5kg di Deadlift equipaggiato.

Adesso non faccio più quei carichi ma il fastidio c'è 😮‍💨
Click to expand...
I want you to understand me correctly — mobility work doesn’t mean stretching every muscle. It’s more about working on the areas that have lost their natural position due to long-term adaptation to powerlifting. As I wrote earlier, without a proper assessment it’s impossible to draw accurate conclusions. But my experience allows me to make some assumptions.

As for the physiotherapist, that’s the right idea. Ideally, they should have experience working with athletes. Before a visit, I usually do diagnostics such as an MRI or ultrasound. Your symptoms don’t sound like an acute injury that would justify spending money on an MRI, but it’s important to understand that the more information the physiotherapist has, the more useful the consultation can be for you. Since it’s unclear exactly which tissues are bothering you, it’s difficult to say whether ultrasound would be useful as a diagnostic method. After your first consultation, please let me know what they recommend.

But the physiotherapist is only the first step. They can give you some useful information, usually in the form of exercises. But an important point is finding the root cause. If the root cause isn’t addressed, none of their recommendations will be effective enough.

What you’re dealing with is actually very common. Very few people who train seriously can completely avoid this kind of injury.

A 180 kg squat and a 192.5 kg deadlift is a very serious level. And that’s exactly why I recommend not only seeing a physiotherapist, but also finding a specialist who can work on developing new movement patterns. That’s a different level of work, but it’s exactly what will allow you to keep progressing.
 
Tina said:
Grazie. Si ho già provveduto al fisioterapista. Vediamo cosa mi consiglia.

Infatti ero in dubbio se usare anche il mots-c o aspettare. Ho sentito tante versioni contrastanti.

Cosa esattamente devo controllare per il "magnesio elementare"? Scusa ma non ho capito bene.
Click to expand...
Tina, if you have doubts about something, then you don’t need to do it. This applies not only to MOTS-C, but to anything else as well. But waiting is a rather unclear decision. Yes, this peptide really doesn’t have enough clinical data, as I wrote earlier, just like the other peptides you’re using, including GHK-Cu. The same goes for the supplements you use — there isn’t enough data on them either to determine exactly how they affect certain processes. All we have are assumptions and data based on a certain number of studies and the experience of enthusiasts.

But we’re on a forum dedicated to these kinds of substances, and the approach of anyone who uses something to boost themselves is, in most cases, experimentation. And it’s exactly the desire to try something new that brings all of us together. What’s important is that everyone clearly understands that this isn’t a medical approach — it’s biohacking. There will always be pros and cons, and there will always be plenty of unknown variables. That’s the nature of the game.

If we reach a point where everything is known, then it becomes a medical recommendation. But medicine as a concept isn’t about trying to improve qualities or functions that are already there. Medicine treats diseases. That’s the conceptual difference, and it’s important to understand it.
 
Tina said:
Adesso mi è chiaro. Graziie 😁
Click to expand...
Regarding magnesium, I got the impression that mentioning the need to look at the amount of elemental magnesium may have confused you.

When I wrote a dosage of 1500 mg of magnesium bisglycinate, I already meant the total weight of the bisglycinate, so as not to complicate the recommendation with unnecessary calculations.

Magnesium bisglycinate consists of magnesium + glycine, so 500 mg of bisglycinate is not 500 mg of pure magnesium. If the product says Magnesium Bisglycinate 500 mg per capsule, then to get 1500 mg of bisglycinate you need to take 3 capsules.

It would be different if the recommendation were 300 mg of elemental magnesium. Then you would indeed need to check the label to see exactly how much elemental magnesium is contained in one capsule of that particular product.

This is where the confusion often comes from: the packaging may say Magnesium 500 mg in large letters, and someone might think they’re getting 500 mg of pure magnesium, while the actual amount of elemental magnesium may be significantly lower.

So in your case it’s simpler: if it says 500 mg of magnesium bisglycinate per capsule, then 1500 mg = 3 capsules.
 
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