Salbutamol and beta-2 receptor

[fluffyde]

Recently started salbutamol from Driada.

So far, very good effect. It clearly makes cardio more enjoyable and feels smoother compared to clenbuterol.

I’m aware that salbutamol is less potent than clen, has a shorter half-life, and therefore in theory should lead to slower beta-2 receptor downregulation.

My question is mainly about receptor sensitivity and long-term usability.

I’m currently not noticing any side effects at all — no tremors, no anxiety, and no negative impact on sleep.

Would running a low dose of 4 mg, 5–6 days per week for longer periods, taken pre-workout, realistically allow me to maintain good receptor sensitivity over time?

Or should I still expect noticeable downregulation even at that dosing pattern?

Interested to hear experiences and any physiology-based input.

 

[SalvatoreCorvus]

Hello.

I was able to try salbutamol in doses of 12-20mg.

I've always noticed a drop in feeling after a week. I know that the feeling has no value but if I try to make the link with the metabolism and the loss of fat linked to this "feeling" I can find some correlation.

The effect is still mild in the end.

In my opinion, it's still a temporary boost (in the stupid and excessively high dosages lol that I used). For performance or to get a light "clen-like" without serious sides.

As for the link with the receptors.. There would be no scientific way to verify the affinity of each one, desensitization or not.

So much for my experience. I don't have a scientific conclusion, just a feeling. With kid gloves